Circulating tumour cells and lung microvascular tumour cell retention in patients with metastatic breast and cervical cancer

Highlights • Pulmonary microvascular obstruction with CTCs can be observed in some patients with metastatic breast and cervical cancer. • We suggest that CTCs might have broader systemic effects beyond their significance as predictors of tumour progression. • This study might provide a glimpse into...

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.872-879
Hauptverfasser:	Peeters, Dieter J.E, Brouwer, Anja, Van den Eynden, Gert G, Rutten, Annemie, Onstenk, Wendy, Sieuwerts, Anieta M, Van Laere, Steven J, Huget, Philippe, Pauwels, Patrick, Peeters, Marc, Vermeulen, Peter B, Dirix, Luc Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - secondary Carcinoma, Lobular - genetics Carcinoma, Lobular - metabolism Carcinoma, Lobular - secondary Cervical cancer Circulating tumour cells Dyspnoea Endothelium Female Follow-Up Studies Gene expression Gene Expression Profiling Hematology, Oncology and Palliative Medicine Humans Liver Lungs Metastasis Metastasis biology Neoplasm Metastasis Neoplasm Staging Neoplastic Cells, Circulating - pathology Neovascularization, Pathologic - pathology Oligonucleotide Array Sequence Analysis Patients Prognosis Prospective Studies Pulmonary tumour cell emboli Retention Studies Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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Zusammenfassung:	Highlights • Pulmonary microvascular obstruction with CTCs can be observed in some patients with metastatic breast and cervical cancer. • We suggest that CTCs might have broader systemic effects beyond their significance as predictors of tumour progression. • This study might provide a glimpse into some of the first steps that might be operative in the formation of metastases.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.10.039