CD4+ T-cells, γδ T-cells and B-cells are associated with lack of vaccine protection in Mycobacterium avium subspecies paratuberculosis infection

Highlights • Not all animals are protected by vaccination against Johne's disease. • Following vaccination, IFNγ and antibody responses are not indicative of disease protection. • We identified early immune responses in sheep that were not protected by vaccination.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-01, Vol.33 (1), p.149-155
Hauptverfasser:	de Silva, Kumudika, M. Plain, Karren, J. Begg, Douglas, C. Purdie, Auriol, J. Whittington, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Bacterial - blood Australia B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology Cell mediated immune response Cell Proliferation Gudair vaccine Interferon-gamma - secretion Johne's disease Mycobacterium avium subsp. paratuberculosis - immunology New Zealand Paratuberculosis - immunology Paratuberculosis - prevention & control Receptors, Antigen, T-Cell, gamma-delta - analysis Sheep T-Lymphocyte Subsets - immunology Treatment Failure Typhoid-Paratyphoid Vaccines - administration & dosage Typhoid-Paratyphoid Vaccines - immunology Vaccine non-response
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Beschreibung
Zusammenfassung:	Highlights • Not all animals are protected by vaccination against Johne's disease. • Following vaccination, IFNγ and antibody responses are not indicative of disease protection. • We identified early immune responses in sheep that were not protected by vaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.10.082