TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma

Highlights • The function of TRPM7 in nasopharyngeal carcinoma (NPC) has remained uncertain. • TRPM7 was closely associated with high metastasis and mortality in NPC patients. • TRPM7 was also found to promote invasion and migration of NPC cells. • TRPM7 might be a novel prognostic and metastasis-re...

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.483-490
Hauptverfasser:	Chen, Jian-Peng, Wang, Jun, Luan, Yi, Wang, Cai-Xia, Li, Wen-Huan, Zhang, Jin-Biao, Sha, Dan, Shen, Rong, Cui, Yan-Gang, Zhang, Zheng, Zhang, Li-Ming, Wang, Wei-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Breast cancer Carcinoma Cell Movement Cell Proliferation Cells, Cultured Classification Confidence intervals Female Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Male Medical prognosis Metastasis Middle Aged Migration Multivariate analysis Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - secondary Nasopharynx - metabolism Nasopharynx - pathology Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Prognosis Protein-Serine-Threonine Kinases Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Studies Survival Rate TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - genetics TRPM Cation Channels - metabolism TRPM7
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Beschreibung
Zusammenfassung:	Highlights • The function of TRPM7 in nasopharyngeal carcinoma (NPC) has remained uncertain. • TRPM7 was closely associated with high metastasis and mortality in NPC patients. • TRPM7 was also found to promote invasion and migration of NPC cells. • TRPM7 might be a novel prognostic and metastasis-related indicator for patients with NPC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.09.032