A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53

Highlights • A34 is the first small peptide derived from p53 linker region. • A34 can interact with iASPP in vitro and in vivo. • A34 can sequester iASPP with p53 and therefore derepress p53. • A34 can increase cell apoptosis and slow tumor growth in vitro and vivo.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.910-917
Hauptverfasser:	Qiu, Shi, Cai, Yun, Gao, Xing, Gu, Shou-Zhi, Liu, Ze-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	A34 Animals Apoptosis Blotting, Western Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell growth Chromatin Immunoprecipitation Derepress Flow Cytometry Genes Hematology, Oncology and Palliative Medicine Humans iASPP Immunoprecipitation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Nude Osteosarcoma - metabolism Osteosarcoma - pathology p53 Peptide Fragments - genetics Peptide Fragments - metabolism Plasmids Repressor Proteins - genetics Repressor Proteins - metabolism Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • A34 is the first small peptide derived from p53 linker region. • A34 can interact with iASPP in vitro and in vivo. • A34 can sequester iASPP with p53 and therefore derepress p53. • A34 can increase cell apoptosis and slow tumor growth in vitro and vivo.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.10.044