Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion

Highlights • RPS3 was identified as a novel downstream gene of GLI2. • Knockdown of GLI2 decreased RPS3 expression in osteosarcoma cells. • RPS3 knockdown decreased the migration and invasion of osteosarcoma cells. • RPS3 expression was increased in primary osteosarcoma lesions with lung metastases....

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.855-861
Hauptverfasser:	Nagao-Kitamoto, Hiroko, Setoguchi, Takao, Kitamoto, Sho, Nakamura, Shunsuke, Tsuru, Arisa, Nagata, Masahito, Nagano, Satoshi, Ishidou, Yasuhiro, Yokouchi, Masahiro, Kitajima, Shinichi, Yoshioka, Takako, Maeda, Shingo, Yonezawa, Suguru, Komiya, Setsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigens Apoptosis Blotting, Western Bone and Bones - metabolism Bone and Bones - pathology Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Adhesion Cell Movement Cell Proliferation Child DNA repair Experiments Female Gene Expression Regulation, Neoplastic GLI2 Hedgehog Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Laboratories Male Medical prognosis Metastasis Middle Aged Neoplasm Invasiveness Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Patients Promoter Regions, Genetic - genetics Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Ribosomal protein S3 (RPS3) Ribosomal Proteins - antagonists & inhibitors Ribosomal Proteins - genetics Ribosomal Proteins - metabolism RNA, Messenger - genetics RNA, Small Interfering - genetics Studies Tumor Cells, Cultured Young Adult Zinc Finger Protein Gli2
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Beschreibung
Zusammenfassung:	Highlights • RPS3 was identified as a novel downstream gene of GLI2. • Knockdown of GLI2 decreased RPS3 expression in osteosarcoma cells. • RPS3 knockdown decreased the migration and invasion of osteosarcoma cells. • RPS3 expression was increased in primary osteosarcoma lesions with lung metastases. • GLI2–RPS3 pathway may be an attractive therapeutic target for treating osteosarcoma metastasis.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.10.042