Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice

Abstract To study whether Lrp11 is involved in stress response and find its expression regulatory network, the model of stress has been built using C57BL/6J (B6) and DBA/2 (D2) mice. Western blotting, qPCR and immunohistochemistry were used to investigate the expression variation of Lrp11 in amygdal...

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Veröffentlicht in:	Psychiatry research 2014-12, Vol.220 (3), p.1131-1137
Hauptverfasser:	Xu, Jian, Cai, Rixin, Lu, Lu, Duan, Chengwei, Tao, Xuelei, Chen, Dongjian, Liu, Yonghua, Wang, Xiaodong, Cao, Maohong, Chen, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - metabolism Animals Biological and medical sciences Expression quantitative trait locus (eQTL) Fundamental and applied biological sciences. Psychology Gene network Gene Regulatory Networks - genetics Hippocampus - metabolism LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - metabolism Lrp11 Male Mice Mice, Inbred C57BL Mice, Inbred DBA Personality. Affectivity Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Quantitative Trait Loci - genetics Recombination, Genetic - genetics Stress Stress, Physiological - genetics
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Zusammenfassung:	Abstract To study whether Lrp11 is involved in stress response and find its expression regulatory network, the model of stress has been built using C57BL/6J (B6) and DBA/2 (D2) mice. Western blotting, qPCR and immunohistochemistry were used to investigate the expression variation of Lrp11 in amygdala tissue after exposure to stress. We found the quantity of Lrp11 was more obvious in stress models than that in normal mice ( P
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2014.09.002