Effects of Exogenous Glucagon-Like Peptide-1 on the Blood Pressure, Heart Rate, Mesenteric Blood Flow, and Glycemic Responses to Intraduodenal Glucose in Healthy Older Subjects
Context: Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). Objective: To determine whether exogenous GLP-1 modulates the ef...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2014-12, Vol.99 (12), p.E2628-E2634 |
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Sprache: | eng |
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Zusammenfassung: | Context:
Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR).
Objective:
To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects.
Design:
A double-blind randomized trial was conducted.
Setting:
Community-dwelling residents attended a clinical research laboratory.
Patients:
Ten healthy “older” subjects (9 male, 1 female; age 73.2 ± 1.5 y) were studied.
Interventions:
Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = −30–60 min). Between t = 0–60 min, ID glucose was infused at 3 kcal/min.
Main Outcome Measures:
BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured.
Results:
During the fasting period (t = −30–0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0–60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05).
Conclusions:
In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow. |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jc.2014-2475 |