Spread and predominance in Japan of novel G1P[8] double-reassortant rotavirus strains possessing a DS-1-like genotype constellation typical of G2P[4] strains

Spread and predominance in Japan of novel G1P[8] double-reassortant rotavirus strains possessing a DS-1-like genotype constellation typical of G2P[4] strains

•Whole genotype constellation of rotaviruses in Japan in 2012 was determined.•Fifty strains carried an unusual G1-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 constellation.•Most of G1P[8] double-reassortants had the genome indistinguishable from each other.•They emerged all three sentinel surveillance locations...

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Veröffentlicht in:Infection, genetics and evolution genetics and evolution, 2014-12, Vol.28, p.426-433
Hauptverfasser: Fujii, Yoshiki, Nakagomi, Toyoko, Nishimura, Naoko, Noguchi, Atsuko, Miura, Sinobu, Ito, Hisato, Doan, Yen Hai, Takahashi, Tsutomu, Ozaki, Takao, Katayama, Kazuhiko, Nakagomi, Osamu
Format: Artikel
Sprache:eng
Schlagworte:
Computational Biology
Evolution
Genome, Viral
Genotype
Genotype constellation
Humans
Japan - epidemiology
Molecular Sequence Data
Phylogeny
Population Surveillance
Reassortant Viruses
Reassortment
RNA, Viral
Rotavirus
Rotavirus - classification
Rotavirus - genetics
Rotavirus Infections - epidemiology
Rotavirus Infections - virology
Sequence Analysis, DNA
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Beschreibung
Zusammenfassung:•Whole genotype constellation of rotaviruses in Japan in 2012 was determined.•Fifty strains carried an unusual G1-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 constellation.•Most of G1P[8] double-reassortants had the genome indistinguishable from each other.•They emerged all three sentinel surveillance locations in Japan.•Their nationwide spread suggests unexpected flexibility in genotype constellation. Rotavirus is a major cause of severe gastroenteritis in children
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2014.08.001