Elevations in cytosolic free Ca super(2+) are not required to trigger apoptosis in human leukaemia cells
Previous studies have indicated that Ca super(2+) is a trigger for apoptosis (programmed cell death) in thymocytes and related cell lines. Recently we have shown that levels of apoptosis in leukaemic cells are diminished in Ca super(2+)-deficient conditions, indicating that Ca super(2+) may be impor...
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Veröffentlicht in: | Clinical and experimental immunology 1992-01, Vol.87 (3), p.465-471 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Previous studies have indicated that Ca super(2+) is a trigger for apoptosis (programmed cell death) in thymocytes and related cell lines. Recently we have shown that levels of apoptosis in leukaemic cells are diminished in Ca super(2+)-deficient conditions, indicating that Ca super(2+) may be important in the mechanism of apoptosis in these cells. In the present study we investigated the possibility that Ca super(2+) serves as a trigger for apoptosis in the human leukaemic cell line, HL-60. The results indicate that elevation of (Ca super(2+)) sub(i) is not a prerequisite for apoptosis in HL-60 cells and that apoptosis can occur in these cells in the presence of low (Ca super(2+)) sub(i). |
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ISSN: | 0009-9104 |