Elevations in cytosolic free Ca super(2+) are not required to trigger apoptosis in human leukaemia cells

Previous studies have indicated that Ca super(2+) is a trigger for apoptosis (programmed cell death) in thymocytes and related cell lines. Recently we have shown that levels of apoptosis in leukaemic cells are diminished in Ca super(2+)-deficient conditions, indicating that Ca super(2+) may be impor...

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Veröffentlicht in:Clinical and experimental immunology 1992-01, Vol.87 (3), p.465-471
Hauptverfasser: Lennon, S V, Kilfeather, SA, Hallett, M B, Campbell, A K, Cotter, T G
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Sprache:eng
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Zusammenfassung:Previous studies have indicated that Ca super(2+) is a trigger for apoptosis (programmed cell death) in thymocytes and related cell lines. Recently we have shown that levels of apoptosis in leukaemic cells are diminished in Ca super(2+)-deficient conditions, indicating that Ca super(2+) may be important in the mechanism of apoptosis in these cells. In the present study we investigated the possibility that Ca super(2+) serves as a trigger for apoptosis in the human leukaemic cell line, HL-60. The results indicate that elevation of (Ca super(2+)) sub(i) is not a prerequisite for apoptosis in HL-60 cells and that apoptosis can occur in these cells in the presence of low (Ca super(2+)) sub(i).
ISSN:0009-9104