Excitatory amino acids and the actions of cocaine

Antagonists of the N-methyl- d-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are...

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Veröffentlicht in:	Brain research 1992-06, Vol.582 (1), p.143-146
Hauptverfasser:	Karler, Ralph, Calder, Larry D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Animals Biological and medical sciences Caffeine - pharmacology Cocaine Cocaine - pharmacology Convulsion Dextromethorphan - pharmacology Dizocilpine Maleate - pharmacology Dopamine Drug addictions Excitatory amino acid Glutamate Haloperidol - pharmacology Male Medical sciences Mice Mice, Inbred Strains Motor Activity - drug effects N-Methyl- d-aspartate N-Methylaspartate - antagonists & inhibitors N-Methylaspartate - pharmacology Pipecolic Acids - pharmacology Quinoxalines - pharmacology Rats Rats, Inbred Strains Rodentia Seizures - chemically induced Seizures - physiopathology Stereoisomerism Stereotyped Behavior - drug effects Toxicology
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Zusammenfassung:	Antagonists of the N-methyl- d-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are an integral component in the reaction sequences involved in the expression of several behavioral effects of cocaine.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(92)90329-8