Isolation and structure of bryostatins 14 and 15

Isolation and structure of bryostatins 14 and 15

Further investigation of constituents from the marine bryozoan Bugula neritina employing new 1,000 kg recollections from the Gulf of Mexico and Eastern Pacific Ocean (California) has led to isolation and structural determination of two previously undetected members of the bryostatin (1-13) series, b...

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Veröffentlicht in:Tetrahedron 1991, Vol.47 (22), p.3601-3610
Hauptverfasser: Pettit, G.R., Gao, F., Sengupta, D., Coll, J.C., Herald, C.L., Doubek, D.L., Schmidt, J.M., van Camp, J.R., Rudloe, J.J., Nieman, R.A.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of complex biological substances
Analytical, structural and metabolic biochemistry
Animal
Biological and medical sciences
Bugula neritina
Fundamental and applied biological sciences. Psychology
Marine
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Zusammenfassung:Further investigation of constituents from the marine bryozoan Bugula neritina employing new 1,000 kg recollections from the Gulf of Mexico and Eastern Pacific Ocean (California) has led to isolation and structural determination of two previously undetected members of the bryostatin (1-13) series, bryostatins 14 (14) and 15 (15). Structural analyses were conducted primarily with high field (400 MHz) NMR and high resolution mass spectral techniques. Both new bryostatins significantly inhibited growth of the P388 lymphocytic leukemia.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)80873-5