Biotransformation of β-thujaplicin by cultured cells of Eucalyptus perriniana

Four β-thujaplicin glycosides were isolated from a cell suspension culture of Eucalyptus perriniana following administration of β-thujaplicin, and their structures determined. Four new biotransformation products, 4-isopropyltropolone 2-O-β- d-glucoside, 4-isopropyltropolone 2-O-β- d-gentiobioside, 6...

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Veröffentlicht in:	Phytochemistry (Oxford) 1997-12, Vol.46 (8), p.1355-1358
Hauptverfasser:	Furuya, Tsutomu, Asada, Yoshihisa, Matsuura, Youichi, Mizobata, Satoshi, Hamada, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies
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creator	Furuya, Tsutomu Asada, Yoshihisa Matsuura, Youichi Mizobata, Satoshi Hamada, Hiroki
description	Four β-thujaplicin glycosides were isolated from a cell suspension culture of Eucalyptus perriniana following administration of β-thujaplicin, and their structures determined. Four new biotransformation products, 4-isopropyltropolone 2-O-β- d-glucoside, 4-isopropyltropolone 2-O-β- d-gentiobioside, 6-isopropyltropolone 2-O-β- d-glucoside and 6-isopropyltropolone 2-O- d-gentiobioside, were isolated from cell suspension culture of Eucalyptus perriniana following administration of β-thujaplicin. The chemical structures of all products were determined by 1H and 13C NMR and MS spectroscopy. It was also observed that the production ratio of biotransformation products was higher in iron-deficient medium than in the medium containing iron ion.
doi_str_mv	10.1016/S0031-9422(97)00463-9
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subjects	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies
title	Biotransformation of β-thujaplicin by cultured cells of Eucalyptus perriniana
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