Number of liver metastatic nodules affects treatment options for pulmonary adenocarcinoma patients with liver metastases

Highlights • Patients with an EGFR mutation tended to have synchronous liver metastasis (LM), and had longer overall-survival (OS) after the development of LM. • Patients with fewer LM nodules had better OS and had less extra-hepatic organ metastasis. • Patients had ≦5 LM nodules could be achieved l...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-11, Vol.86 (2), p.225-230
Hauptverfasser:	Tseng, Shih-En, Chiou, Yi-You, Lee, Yu-Chin, Perng, Reury-Perng, Jacqueline, Whang-Peng, Chen, Yuh-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma - therapy Adenocarcinoma of Lung Aged Biological and medical sciences Combined Modality Therapy Epidermal growth factor receptor (EGFR) ErbB Receptors - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Hematology, Oncology and Palliative Medicine Humans Liver metastasis Liver Neoplasms - diagnosis Liver Neoplasms - pathology Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - therapy Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Pneumology Prognosis Prognostic factors Pulmonary adenocarcinoma Pulmonary/Respiratory Radiofrequency ablation (RFA) Risk Factors Survival Treatment Outcome Tumor Burden Tumors Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Highlights • Patients with an EGFR mutation tended to have synchronous liver metastasis (LM), and had longer overall-survival (OS) after the development of LM. • Patients with fewer LM nodules had better OS and had less extra-hepatic organ metastasis. • Patients had ≦5 LM nodules could be achieved long-term survival if they received RFA in addition to systemic therapy.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2014.09.002