Association study between salivary levels of interferon (IFN)-gamma, interleukin (IL)-17, IL-21, and IL-22 with chronic periodontitis

Highlights • IFN-γ and/or Th17 cytokines might play a role in the etiopathogenesis of CP. • Saliva samples may reflect the biological changes related to tissular damage observed in CP. • Disease status showed a strong association with salivary levels of IFN-γ and IFN-γ/IL-22 ratio. • Th17 cytokines...

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Veröffentlicht in:	Archives of oral biology 2015-01, Vol.60 (1), p.91-99
Hauptverfasser:	Isaza-Guzmán, D.M, Cardona-Vélez, N, Gaviria-Correa, D.E, Martínez-Pabón, M.C, Castaño-Granada, M.C, Tobón-Arroyave, S.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced Basic Science Biomarkers - metabolism Case-Control Studies Chronic periodontitis Chronic Periodontitis - metabolism Cross-Sectional Studies Dentistry Enzyme-Linked Immunosorbent Assay Female Humans IFN-γ IL-17 IL-21 IL-22 Interferon-gamma - metabolism Interleukin-17 - metabolism Interleukin-22 Interleukins - metabolism Male Middle Aged Predictive Value of Tests Reproducibility of Results Saliva Saliva - chemistry
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Beschreibung
Zusammenfassung:	Highlights • IFN-γ and/or Th17 cytokines might play a role in the etiopathogenesis of CP. • Saliva samples may reflect the biological changes related to tissular damage observed in CP. • Disease status showed a strong association with salivary levels of IFN-γ and IFN-γ/IL-22 ratio. • Th17 cytokines were not of predictive value for health/disease status. • Age stratum showed a synergistic interaction effect on IFN-γ levels.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2014.09.002