Influenza vaccine effectiveness estimates for Western Australia during a period of vaccine and virus strain stability, 2010 to 2012

Highlights • Data were pooled across 2010–2012, years during which the vaccine composition was unaltered. • Vaccine effectiveness estimates were made by year and subtype and indicated no significant decline in vaccine effectiveness across years. • Estimates were highest against H1 and lowest against...

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Veröffentlicht in:	Vaccine 2014-10, Vol.32 (47), p.6312-6318
Hauptverfasser:	Levy, Avram, Sullivan, Sheena G, Tempone, Simone S, Wong, Kerry L.M, Regan, Annette K, Dowse, Gary K, Effler, Paul V, Smith, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Allergy and Immunology Applied microbiology Biological and medical sciences Case-Control Studies Child Child, Preschool Data pooling Estimates Family medical history Female Fundamental and applied biological sciences. Psychology Humans Illnesses Infant Infant, Newborn Influenza Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza B virus Influenza season Influenza vaccine Influenza Vaccines - immunology Influenza Vaccines - therapeutic use Influenza virus Influenza, Human - epidemiology Influenza, Human - prevention & control Influenza, Human - virology Influenza-like illness Laboratories Male Microbiology Middle Aged Odds Ratio Patients Sentinel Surveillance Surveillance Vaccine effectiveness Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viruses Western Australia - epidemiology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Data were pooled across 2010–2012, years during which the vaccine composition was unaltered. • Vaccine effectiveness estimates were made by year and subtype and indicated no significant decline in vaccine effectiveness across years. • Estimates were highest against H1 and lowest against H3. • When using noninfluenza virus-positive controls VE estimates were slightly higher, perhaps owing to improvements in outcome sensitivity. • Comparison of estimates within and out of the season suggested little effect of the vaccine outside the season.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.08.066