The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Dysregulated endoplasmic reticulum (ER) calcium (Ca 2+ ) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca 2+ release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are up...

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Veröffentlicht in:	Channels (Austin, Tex.) Tex.), 2014-05, Vol.8 (3), p.230-242
Hauptverfasser:	Liu, Jie, Supnet, Charlene, Sun, Suya, Zhang, Hua, Good, Levi, Popugaeva, Elena, Bezprozvanny, Ilya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism amyloid load Animals Arc caffeine Disease Models, Animal EEG Hippocampus - metabolism Humans Mice Mice, Inbred C57BL Mice, Knockout Neurons - metabolism Research Paper ryanodine receptor Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism spine morphology spontaneous activity
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Zusammenfassung:	Dysregulated endoplasmic reticulum (ER) calcium (Ca 2+ ) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca 2+ release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD models and RyanR expression and activity are upregulated in the brains of various familial AD (FAD) models. The objective of this study was to utilize a genetic approach to evaluate the importance of RyanR type 3 (RyanR3) in the context of AD pathology.
ISSN:	1933-6950 1933-6969
DOI:	10.4161/chan.27471