Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells

Highlights • The vitamin D metabolite calcidiol inhibits DC maturation and modifies DC cytokine production. • Calcidiol-primed DCs induce suppressive IL-10 producing Treg cells. • Treg cells induced by calcidiol-primed DCs produce IFN-γ. • Calcidiol is a potential regulatory adjuvant that can improv...

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Veröffentlicht in:	Vaccine 2014-10, Vol.32 (47), p.6294-6302
Hauptverfasser:	Bakdash, Ghaith, van Capel, Toni M.M, Mason, Lauren M.K, Kapsenberg, Martien L, de Jong, Esther C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergen-specific immunotherapy Allergy and Immunology Applied microbiology Biological and medical sciences Calcidiol Calcifediol - pharmacology Cells, Cultured Cholecalciferol - pharmacology Clinical trials Coculture Techniques Dendritic Cells - drug effects Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Humans Immune system Immunology Interferon-gamma - biosynthesis Interleukin-10 - biosynthesis Lymphocytes Metabolites Microbiology Side effects Studies T-Lymphocytes, Regulatory - immunology Treg Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vitamin D Vitamin deficiency
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Zusammenfassung:	Highlights • The vitamin D metabolite calcidiol inhibits DC maturation and modifies DC cytokine production. • Calcidiol-primed DCs induce suppressive IL-10 producing Treg cells. • Treg cells induced by calcidiol-primed DCs produce IFN-γ. • Calcidiol is a potential regulatory adjuvant that can improve allergen-specific immunotherapy.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.08.075