Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway

Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer epidemiology 2014-12, Vol.38 (6), p.765-772
Hauptverfasser:	Khan, Arif, Aljarbou, Ahmad N, Aldebasi, Yousef H, Faisal, Syed M, Khan, Masood A
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Analysis. Health state Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - therapeutic use Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Cell cycle Cell growth Cell Line, Tumor Cell Proliferation Epidemiology FASN Female General aspects Hematology, Oncology and Palliative Medicine Her2 Humans Internal Medicine Kinases Medical sciences PI3K Public health. Hygiene Public health. Hygiene-occupational medicine Receptor, ErbB-2 - metabolism Resveratrol Signal Transduction SKBR-3 Stilbenes - administration & dosage Stilbenes - therapeutic use Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.
ISSN:	1877-7821 1877-783X
DOI:	10.1016/j.canep.2014.09.006