Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway

Highlights • Nuclear overexpression of YAP1 was linked to poor prognosis with GBC. • This study examined the mechanistic roles of YAP1 in GBC. • YAP1 promotes GBC cell growth via activation of the AXL/MAPK pathway. • This work provided a rationale for YAP1 as a therapeutic target for GBC.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-12, Vol.355 (2), p.201-209
Hauptverfasser:	Li, Maolan, Lu, Jianhua, Zhang, Fei, Li, Huaifeng, Zhang, Bingtai, Wu, Xiangsong, Tan, Zhujun, Zhang, Lin, Gao, Guofeng, Mu, Jiasheng, Shu, Yijun, Bao, Runfa, Ding, Qichen, Wu, Wenguang, Dong, Ping, Gu, Jun, Liu, Yingbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis - physiology Cell cycle arrest Cell growth Cell Line, Tumor Cell Nucleus - metabolism Cell proliferation Cell Proliferation - physiology Enzyme Activation Gallbladder cancer Gallbladder Neoplasms - genetics Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - pathology Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Heterografts Humans Kinases MAP Kinase Signaling System Mice Mice, Nude Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mortality Oncogenes Phosphoproteins - biosynthesis Phosphoproteins - genetics Phosphoproteins - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism RNA interference S Phase - physiology Studies Transcription Factors YAP1
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Beschreibung
Zusammenfassung:	Highlights • Nuclear overexpression of YAP1 was linked to poor prognosis with GBC. • This study examined the mechanistic roles of YAP1 in GBC. • YAP1 promotes GBC cell growth via activation of the AXL/MAPK pathway. • This work provided a rationale for YAP1 as a therapeutic target for GBC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.036