Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia

EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from he...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2015-01, Vol.54 (1), p.97-102
Hauptverfasser:	Rabello, Doralina do Amaral, Lucena-Araujo, Antonio Roberto, Alves-Silva, Juliana Carvalho Rocha, da Eira, Vinícius Burnett Aboud Souza, de Vasconcellos, Maria Catarina Cals, de Oliveira, Fábio Morato, Rego, Eduardo Magalhaes, Saldanha-Araujo, Felipe, Pittella Silva, Fábio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Chronic lymphocytic leukemia Cytogenetic Enhancer of Zeste Homolog 2 Protein EZH2 Female Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Leukemic Histone methyltransferase Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Male Middle Aged Polycomb Repressive Complex 2 - biosynthesis Prognosis Real-Time Polymerase Chain Reaction ZAP-70 Protein-Tyrosine Kinase - biosynthesis
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Zusammenfassung:	EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from healthy donors and 12 normal adult tissues. EZH2 was overexpressed in CLL patients and correlates with high white blood cell count, ZAP-70 expression and chromosomal abnormalities. EHZ1 expression does not correlate with CLL progression. EZH2 overexpression is related to a poor prognosis of CLL and could be a useful tool to assess its aggressiveness.
ISSN:	1079-9796 1096-0961
DOI:	10.1016/j.bcmd.2014.07.013