The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences
Highlights • We review mechanisms by which radiotherapy can influence tumor immunogenicity. • We focus on systemic consequences of irradiation on the antitumor immunity. • Immunotherapeutic approaches that act in synergism with radiotherapy are presented. • Possible immunological markers predictive...
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| Veröffentlicht in: | Cancer letters 2015-01, Vol.356 (1), p.114-125 |
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| container_end_page | 125 |
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| container_issue | 1 |
| container_start_page | 114 |
| container_title | Cancer letters |
| container_volume | 356 |
| creator | Lumniczky, Katalin Sáfrány, Géza |
| description | Highlights • We review mechanisms by which radiotherapy can influence tumor immunogenicity. • We focus on systemic consequences of irradiation on the antitumor immunity. • Immunotherapeutic approaches that act in synergism with radiotherapy are presented. • Possible immunological markers predictive for radiotherapy response are reviewed. |
| doi_str_mv | 10.1016/j.canlet.2013.08.024 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2015-01, Vol.356 (1), p.114-125 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antigens, Neoplasm - immunology Apoptosis - immunology Bystander Bystander Effect - immunology Bystander Effect - radiation effects Cancer Cancer therapies Chemokines Cytokines Cytokines - biosynthesis Cytokines - secretion Cytotoxicity Dendritic Cells - immunology Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Immune system Immune therapy Immunology Immunomodulation - immunology Immunomodulation - radiation effects Macrophages - immunology Medical research Melanoma Neoplasm Proteins - immunology Neoplasms - immunology Neoplasms - radiotherapy Peptides Radiation therapy Radiotherapy Studies T cell receptors T-Lymphocytes - immunology Tumor Tumor Escape - immunology Tumor Escape - radiation effects Tumor Microenvironment - immunology Tumors |
| title | The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences |
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