The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences

Highlights • We review mechanisms by which radiotherapy can influence tumor immunogenicity. • We focus on systemic consequences of irradiation on the antitumor immunity. • Immunotherapeutic approaches that act in synergism with radiotherapy are presented. • Possible immunological markers predictive...

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (1), p.114-125
Hauptverfasser:	Lumniczky, Katalin, Sáfrány, Géza
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology Apoptosis - immunology Bystander Bystander Effect - immunology Bystander Effect - radiation effects Cancer Cancer therapies Chemokines Cytokines Cytokines - biosynthesis Cytokines - secretion Cytotoxicity Dendritic Cells - immunology Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Immune system Immune therapy Immunology Immunomodulation - immunology Immunomodulation - radiation effects Macrophages - immunology Medical research Melanoma Neoplasm Proteins - immunology Neoplasms - immunology Neoplasms - radiotherapy Peptides Radiation therapy Radiotherapy Studies T cell receptors T-Lymphocytes - immunology Tumor Tumor Escape - immunology Tumor Escape - radiation effects Tumor Microenvironment - immunology Tumors
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Beschreibung
Zusammenfassung:	Highlights • We review mechanisms by which radiotherapy can influence tumor immunogenicity. • We focus on systemic consequences of irradiation on the antitumor immunity. • Immunotherapeutic approaches that act in synergism with radiotherapy are presented. • Possible immunological markers predictive for radiotherapy response are reviewed.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.08.024