Contribution of Recurrent Venous Thrombosis and Inherited Thrombophilia to the Pathogenesis of Postthrombotic Syndrome
Postthrombotic syndrome (PTS) is a common complication of deep vein thrombosis. This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively rev...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2015-01, Vol.21 (1), p.87-90 |
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| description | Postthrombotic syndrome (PTS) is a common complication of deep vein thrombosis. This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and |
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This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029613497423</identifier><identifier>PMID: 23892685</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Health risk assessment ; Humans ; Male ; Middle Aged ; Pathogenesis ; Postthrombotic Syndrome - etiology ; Postthrombotic Syndrome - physiopathology ; Recurrence ; Retrospective Studies ; Risk Factors ; Thrombophilia - complications ; Thrombosis ; Vascular Surgical Procedures ; Venous Thrombosis - complications ; Venous Thrombosis - surgery</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2015-01, Vol.21 (1), p.87-90</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013.</rights><rights>The Author(s) 2013. 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This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Postthrombotic Syndrome - etiology</subject><subject>Postthrombotic Syndrome - physiopathology</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Thrombophilia - complications</subject><subject>Thrombosis</subject><subject>Vascular Surgical Procedures</subject><subject>Venous Thrombosis - complications</subject><subject>Venous Thrombosis - surgery</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kUtrGzEUhUVpSFwn-66KoJtuptH7sSwmaQOBhLy2w1hzx6NgS66kCeTfV8ZJC4aixZU43z26l4PQZ0q-U6r1OSVaEWYV5cJqwfgHNKOWm4Zpxj_We5WbnX6CPuX8TAi1yqpjdMK4sUwZOUMvixhK8sup-BhwHPAduCklCAU_QYhTxg9jiptlzD7jLvT4KoyQfIH-XdiOfu07XCIuI-DbroxxBQF2fLW7jbmUPVi8w_evoa8POEVHQ7fOcPZW5-jx8uJh8au5vvl5tfhx3TiuZGmccVoYZ6hQdXAq9FIOvSGs3x3ZSapYb7gZpDagQFsqDamqdkJKRozkc_Rt77tN8fcEubQbnx2s112AulxbDaxVXFFV0a8H6HOcUqjTtYwLQS0zwlSK7CmXYs4Jhnab_KZLry0l7S6T9jCT2vLlzXhabqD_2_AeQgWaPZC7Ffz79b-GfwAFxpOy</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Kreidy, Raghid</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Contribution of Recurrent Venous Thrombosis and Inherited Thrombophilia to the Pathogenesis of Postthrombotic Syndrome</title><author>Kreidy, Raghid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-c8c748c8146696147b5fd802d2d2d5a5162d838f578e6e79158002d7c45520853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Postthrombotic Syndrome - etiology</topic><topic>Postthrombotic Syndrome - physiopathology</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Thrombophilia - complications</topic><topic>Thrombosis</topic><topic>Vascular Surgical Procedures</topic><topic>Venous Thrombosis - complications</topic><topic>Venous Thrombosis - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kreidy, Raghid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23892685</pmid><doi>10.1177/1076029613497423</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Female Health risk assessment Humans Male Middle Aged Pathogenesis Postthrombotic Syndrome - etiology Postthrombotic Syndrome - physiopathology Recurrence Retrospective Studies Risk Factors Thrombophilia - complications Thrombosis Vascular Surgical Procedures Venous Thrombosis - complications Venous Thrombosis - surgery |
| title | Contribution of Recurrent Venous Thrombosis and Inherited Thrombophilia to the Pathogenesis of Postthrombotic Syndrome |
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