JAK2 V617F Mutation Status of 232 Patients Diagnosed With Chronic Myeloproliferative Neoplasms

Micro-Abstract The aim of this study was to investigate the presence of Janus kinase 2 (JAK2) V617F mutation in patients with BCR-ABL negative chronic myeloproliferative neoplasms (CMPNs) in our center. JAK2 V617F mutation frequencies in our PV and ET patients were similar to those reported previous...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2014-12, Vol.14 (6), p.525-533
Hauptverfasser:	Payzin, Kadriye Bahriye, Savasoglu, Kaan, Alacacioglu, Inci, Ozdemirkiran, Fusun, Mutlu, Belgin Berber, Bener, Sadi, Calli, Aylin Orgen, Kucukzeybek, Betul Bolat, Aksun, Saliha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Alleles Chronic Disease Codon Disease Progression Essential thrombocythemia Female Follow-Up Studies Genotype Hematology, Oncology and Palliative Medicine Humans JAK2 mutation Janus Kinase 2 - genetics Male Middle Aged MPNs Mutation Myeloproliferative Disorders - complications Myeloproliferative Disorders - diagnosis Myeloproliferative Disorders - drug therapy Myeloproliferative Disorders - genetics Myeloproliferative Disorders - mortality Phenotype Polycythemia vera Primary myelofibrosis Thrombosis - etiology Treatment Outcome Young Adult
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Zusammenfassung:	Micro-Abstract The aim of this study was to investigate the presence of Janus kinase 2 (JAK2) V617F mutation in patients with BCR-ABL negative chronic myeloproliferative neoplasms (CMPNs) in our center. JAK2 V617F mutation frequencies in our PV and ET patients were similar to those reported previously. JAK2 V617F mutation frequency in our PMF patients was greater than in previous reports.
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2014.02.013