Endocrinological outcomes following endoscopic and microscopic transsphenoidal surgery in 113 patients with acromegaly

Highlights • A recent consensus has imposed strict targets for surgical remission in acromegalic patients. • We present outcomes with endoscopic and microscopic transsphenoidal surgery. • Large, invasive adenomas with high hormonal levels are poor prognostic factors. • Biochemical outcomes with endo...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2014-11, Vol.126, p.190-195
Hauptverfasser:	Sarkar, Sauradeep, Rajaratnam, Simon, Chacko, Geeta, Chacko, Ari George
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly Acromegaly - etiology Acromegaly - metabolism Acromegaly - surgery Adenoma - complications Adenoma - metabolism Adenoma - surgery Adult Age Catheters Confidence intervals Female Growth hormone Growth Hormone-Secreting Pituitary Adenoma - complications Growth Hormone-Secreting Pituitary Adenoma - metabolism Growth Hormone-Secreting Pituitary Adenoma - surgery Humans Hypothyroidism Insulin-like growth factors Male Medical imaging Microsurgery - standards Middle Aged Neuroendoscopy - standards Neurology Neurosurgery Patients Pituitary adenoma Pituitary gland Sinuses Sphenoid Bone - surgery Surgery Transsphenoidal surgery Treatment Outcome Tumors
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Zusammenfassung:	Highlights • A recent consensus has imposed strict targets for surgical remission in acromegalic patients. • We present outcomes with endoscopic and microscopic transsphenoidal surgery. • Large, invasive adenomas with high hormonal levels are poor prognostic factors. • Biochemical outcomes with endoscopic and microsurgical surgery were similar. • Preservation of pituitary function is superior with endoscopy.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2014.09.004