Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model

Highlights • Tenascin C is upregulated in pilocarpine model. • TGF-β signaling pathway involve TNC overproduction. • TGFβR1 inhibitor partially reverts the TNC content.

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Bibliographische Detailangaben
Veröffentlicht in:	Epilepsy research 2014-12, Vol.108 (10), p.1694-1704
Hauptverfasser:	Mercado-Gómez, Octavio, Landgrave-Gómez, Jorge, Arriaga-Avila, Virginia, Nebreda-Corona, Adriana, Guevara-Guzmán, Rosalinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Biological and medical sciences Cell Nucleus - drug effects Cell Nucleus - metabolism Central Nervous System Agents - pharmacology Cytoplasm - drug effects Cytoplasm - metabolism Dioxoles - pharmacology Disease Models, Animal Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - drug effects Hippocampus - metabolism Male Medical sciences Nervous system (semeiology, syndromes) Neurology Phospho-Smad2/3 Phosphorylation Pilocarpine Protein-Serine-Threonine Kinases - metabolism Rats, Wistar Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta - metabolism Seizures - metabolism Signal Transduction - drug effects Smad2 Protein - metabolism Smad3 Protein - metabolism Status epilepticus Tenascin - metabolism Tenascin C Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - metabolism Transforming growth factor β Up-Regulation - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Tenascin C is upregulated in pilocarpine model. • TGF-β signaling pathway involve TNC overproduction. • TGFβR1 inhibitor partially reverts the TNC content.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2014.09.019