Significant impact of behavioral and cognitive impairment on quality of life in patients with myotonic dystrophy type 1

Highlights • Patients with juvenile form of DM1 had lower quality of life than adult onset DM1 patients. • Significant predictors of quality of life in patients with juvenile onset DM1 were fatigue and visuospatial abilities. • Significant predictors of quality of life in patients with adult onset D...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2014-11, Vol.126, p.76-81
Hauptverfasser:	Rakocevic-Stojanovic, V, Peric, S, Madzarevic, R, Dobricic, V, Ralic, V, Ilic, V, Basta, I, Nikolic, A, Stefanova, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age of Onset Anxiety Behavior Children & youth Cognition Cognition Disorders - etiology Cognition Disorders - physiopathology Cohort Studies Colleges & universities Educational Status Fatigue Fatigue - etiology Fatigue - physiopathology Female Humans Male Memory Middle Aged Myotonic Dystrophy - complications Myotonic Dystrophy - physiopathology Myotonic dystrophy type 1 Nervous system Neurology Neurosurgery Patients Quality of Life Regression analysis Standard deviation Variables Young Adult
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Zusammenfassung:	Highlights • Patients with juvenile form of DM1 had lower quality of life than adult onset DM1 patients. • Significant predictors of quality of life in patients with juvenile onset DM1 were fatigue and visuospatial abilities. • Significant predictors of quality of life in patients with adult onset DM1 were fatigue and level of education. • Clear influence of different central manifestations on quality of life was found in patients with DM1.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2014.08.021