Immunosenescence and vaccine failure in the elderly: Strategies for improving response
Highlights • The immune response in the elderly is anomalous as compared to that of young and adult individuals. • Vaccines designed for children and adults may be less effective in the elderly population. • Vaccine design requires knowledge of the immunosenescence mechanisms and of the individual p...
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| Veröffentlicht in: | Immunology letters 2014-11, Vol.162 (1), p.346-353 |
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| container_end_page | 353 |
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| container_title | Immunology letters |
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| creator | Boraschi, Diana Italiani, Paola |
| description | Highlights • The immune response in the elderly is anomalous as compared to that of young and adult individuals. • Vaccines designed for children and adults may be less effective in the elderly population. • Vaccine design requires knowledge of the immunosenescence mechanisms and of the individual past history of exposure/immunity. • Current vaccination strategies are still not personalised, but act on improving various aspects of vaccination. • These include increased/repeated vaccine dosing, different administration routes, use of adjuvants, and new delivery systems. |
| doi_str_mv | 10.1016/j.imlet.2014.06.006 |
| format | Article |
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| ispartof | Immunology letters, 2014-11, Vol.162 (1), p.346-353 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age Factors Aged Aged, 80 and over Aging - immunology Allergy and Immunology Elderly Humans Immunity - physiology Immunosenescence Vaccination Vaccination - methods Vaccines - administration & dosage Vaccines - immunology |
| title | Immunosenescence and vaccine failure in the elderly: Strategies for improving response |
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