Activity of cathepsin D and alpha-1 antitrypsin in patients with hip or knee osteoarthritis

To assess the activity of cathepsin D (CAT-D) and alpha-1 antitrypsin (AAT) in blood in patients with hip or knee osteoarthritis, and to explore whether these two enzymes could be served as serum biomarkers for cartilage degeneration. Th e activity of CAT-D and AAT in blood serum of 44 women and 26...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2014-11, Vol.39 (11), p.1151-1156
Hauptverfasser:	Xia, Hong, Huang, Jiaqiang, Mao, Fuqing, Peng, Ke, Hu, Xu
Format:	Artikel
Sprache:	chi
Schlagworte:	alpha 1-Antitrypsin - blood alpha 1-Antitrypsin - metabolism Biomarkers - blood Biomarkers - metabolism Cathepsin D - blood Cathepsin D - metabolism Female Humans Male Osteoarthritis, Knee - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To assess the activity of cathepsin D (CAT-D) and alpha-1 antitrypsin (AAT) in blood in patients with hip or knee osteoarthritis, and to explore whether these two enzymes could be served as serum biomarkers for cartilage degeneration. Th e activity of CAT-D and AAT in blood serum of 44 women and 26 men with hip or knee osteoarthritis was determined by the method of ELISA before total joint replacement and on the 10th day aft er the surgery. One hundred healthy volunteers were chosen as the control. All data were analyzed by using SPSS19.0 software. Compared with the controls, the activity of CAT-D in patients with osteoarthritis was decreased by 25% (P
ISSN:	1672-7347
DOI:	10.11817/j.issn.1672-7347.2014.11.008