Synthesis of 5-(Fluoromethyl)-4,5-dihydroisoxazoles by Silver- Catalyzed Oxyfluorination of Unactivated Alkenes

Synthesis of 5-(Fluoromethyl)-4,5-dihydroisoxazoles by Silver- Catalyzed Oxyfluorination of Unactivated Alkenes

A new silver‐catalyzed oxyfluorination of unactivated alkenes using commercially available Selectfluor as the fluorine source is presented. This method provides a new access to 5‐(fluoromethyl)‐4,5‐dihydroisoxazoles, and represents a new example of alkene 1,2‐difunctionalization by simultaneously fo...

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Veröffentlicht in:Advanced synthesis & catalysis 2014-10, Vol.356 (14-15), p.2913-2918
Hauptverfasser: Liu, Yan-Yun, Yang, Ji, Song, Ren-Jie, Li, Jin-Heng
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Catalysis
Fluorine
Forming
isoxazoles
oxyfluorination
Selectfluor
silver
Synthesis
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Zusammenfassung:A new silver‐catalyzed oxyfluorination of unactivated alkenes using commercially available Selectfluor as the fluorine source is presented. This method provides a new access to 5‐(fluoromethyl)‐4,5‐dihydroisoxazoles, and represents a new example of alkene 1,2‐difunctionalization by simultaneously forming two new carbon‐heteroatom bonds.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400242