Prevention of binding of rgp120 by anti-HIV active tannins

Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587–595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgpl20 to CD4. These compounds were not toxic to stimulated human peripheral blood l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1992-06, Vol.43 (11), p.2479-2480
Hauptverfasser:	Weaver, James L., Pine, P.Scott, Dutschman, Ginger, Cheng, Yung-Chi, Lee, Kuo-Hsing, Aszalos, Adorjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents antiviral activity Antiviral agents Antiviral Agents - pharmacology binding Biological and medical sciences CD4 antigen CD4 Antigens - metabolism Drug Design flow cytometry glycoprotein gp120 HIV Envelope Protein gp120 - metabolism human immunodeficiency virus Humans Lymphocytes - drug effects Lymphocytes - immunology Medical sciences Pharmacology. Drug treatments Protein Binding - drug effects Recombinant Proteins - metabolism tannins Tannins - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587–595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgpl20 to CD4. These compounds were not toxic to stimulated human peripheral blood lymphocytes at concentrations ten times above their maximal effective concentration.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(92)90328-G