Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal

This study aims to evaluate the efficacy of myrtenal, a natural monoterpene, for its antihyperglycemic effects and β cell protective properties in streptozotocin (STZ)-induced diabetic rats. Oral administration of myrtenal at doses of 20, 40, and 80 mg/kg body weight to diabetic rats for 28 days res...

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Veröffentlicht in:	Journal of physiology and biochemistry 2014-12, Vol.70 (4), p.935-946
Hauptverfasser:	Rathinam, Ayyasamy, Pari, Leelavinothan, Chandramohan, Ramasamy, Sheikh, Bashir Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animal Physiology Animals Biomedical and Life Sciences Biomedicine Carbohydrate Metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Drug Evaluation, Preclinical Fructose-Bisphosphatase - metabolism Glucose-6-Phosphatase - metabolism Glucosephosphate Dehydrogenase - metabolism Glycogen - metabolism Hexokinase - metabolism Human Physiology Hypoglycemic Agents - administration & dosage Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Liver - pathology Male Muscle, Skeletal - metabolism Original Paper Pancreas - drug effects Pancreas - enzymology Pancreas - pathology Rats, Wistar Streptozocin Terpenes - administration & dosage
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Zusammenfassung:	This study aims to evaluate the efficacy of myrtenal, a natural monoterpene, for its antihyperglycemic effects and β cell protective properties in streptozotocin (STZ)-induced diabetic rats. Oral administration of myrtenal at doses of 20, 40, and 80 mg/kg body weight to diabetic rats for 28 days resulted in a significant reduction ( P
ISSN:	1138-7548 1877-8755
DOI:	10.1007/s13105-014-0362-z