Terpenoids from the Root Bark of Pterolobium macropterum

Five new compounds, including pteroloterins A–C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compoun...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2014-11, Vol.77 (11), p.2432-2437
Hauptverfasser:	Suthiwong, Jittra, Pitchuanchom, Siripit, Wattanawongdon, Wareeporn, Hahnvajanawong, Chariya, Yenjai, Chavi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Bile Duct Neoplasms Bile Ducts, Intrahepatic Cell Line, Tumor Cholangiocarcinoma Drug Screening Assays, Antitumor Fabaceae - chemistry Humans Inhibitory Concentration 50 Molecular Structure Osteogenesis - drug effects Plant Bark - chemistry Structure-Activity Relationship Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Thailand
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Beschreibung
Zusammenfassung:	Five new compounds, including pteroloterins A–C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 μM and showed no activity against normal cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np500476h