Loss of function of SWI/SNF chromatin remodeling genes leads to genome instability of human lung cancer

Loss of function of SWI/SNF chromatin remodeling genes leads to genome instability of human lung cancer

SWI/SNF chromatin remodeling complexes are frequently mutated in a variety of human cancers. We investigated the mutation incidence and the role of mSWI/SNF (BAF) complexes in human lung cancer. In the present study, we analyzed somatic mutations of BAF complexes and other driver mutated genes of lu...

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Veröffentlicht in:Oncology reports 2015-01, Vol.33 (1), p.283-291
Hauptverfasser: HUANG, HAI-TAO, CHEN, SHAO-MU, PAN, LIANG-BIN, YAO, JIE, MA, HAI-TAO
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line, Tumor
Chromatin Assembly and Disassembly - genetics
Cloning
Deoxyribonucleic acid
DNA
DNA Helicases - genetics
DNA repair
DNA-Binding Proteins - genetics
Gene Frequency
Gene mutations
Genes
Genetic aspects
genome instability
Genomes
Genomic Instability
Health aspects
Humans
Identification and classification
Luciferase
Lung cancer
Lung Neoplasms - genetics
Mutation
Mutation Rate
mutation reporter
Nuclear Proteins - genetics
Physiological aspects
Risk factors
slippage-luciferase
SWI/SNF
Transcription Factors - genetics
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Zusammenfassung:SWI/SNF chromatin remodeling complexes are frequently mutated in a variety of human cancers. We investigated the mutation incidence and the role of mSWI/SNF (BAF) complexes in human lung cancer. In the present study, we analyzed somatic mutations of BAF complexes and other driver mutated genes of lung carcinoma deposited in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. BAF complexes were mutated in 282 of 803 (35.12%) lung carcinoma samples analyzed, ranking second to TP53. Significantly, BAF-mutated samples exhibited more genomic mutations than BAF wild-type ones. Moreover, a significant positive correlation existed between the BAF mutations and overall genomic mutations in these lung carcinoma samples (P
ISSN:1021-335X
1791-2431
DOI:10.3892/or.2014.3584