Evolution of Practice During the Interventional Management of Stroke III Trial and Implications for Ongoing Trials

Evolution of Practice During the Interventional Management of Stroke III Trial and Implications for Ongoing Trials

BACKGROUND AND PURPOSE—We explored changes in the patient population and practice of endovascular therapy during the course of the Interventional Management of Stroke (IMS) III Trial. METHODS—Changes in baseline characteristics, use of baseline CT angiography, treatment times and specifics, and outc...

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Veröffentlicht in:Stroke (1970) 2014-12, Vol.45 (12), p.3606-3611
Hauptverfasser: Broderick, Joseph P, Palesch, Yuko Y, Demchuk, Andrew M, Yeatts, Sharon D, Khatri, Pooja, Hill, Michael D, Jauch, Edward C, Jovin, Tudor G, Yan, Bernard, von Kummer, Rüdiger, Molina, Carlos A, Goyal, Mayank, Mazighi, Mikael, Schonewille, Wouter J, Engelter, Stefan T, Anderson, Craig, Spilker, Judith, Carrozzella, Janice, Janis, L Scott, Foster, Lydia D, Tomsick, Thomas A
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cerebral Angiography
Clinical Trials, Phase III as Topic
Endovascular Procedures - methods
Female
Fibrinolytic Agents - therapeutic use
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Injections, Intra-Arterial
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Research Design
Stroke - therapy
Thrombectomy - methods
Thrombolytic Therapy - methods
Time Factors
Tissue Plasminogen Activator - administration & dosage
Vascular diseases and vascular malformations of the nervous system
Young Adult
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Zusammenfassung:BACKGROUND AND PURPOSE—We explored changes in the patient population and practice of endovascular therapy during the course of the Interventional Management of Stroke (IMS) III Trial. METHODS—Changes in baseline characteristics, use of baseline CT angiography, treatment times and specifics, and outcomes were compared between the first 4 protocols and the fifth and final protocol. RESULTS—Compared with subjects treated in the first 4 protocol versions (n=610), subjects treated in fifth and final protocol (n=46) were older (75 versus 68 years, P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.114.005952