Generation of induced neurons by direct reprogramming in the mammalian cochlea

Generation of induced neurons by direct reprogramming in the mammalian cochlea

Highlights • Ascl1 induces neurons at high efficiency in the embryonic, postnatal and juvenile mouse cochlea. • Ascl1-induced neurons express several neuronal markers including synaptic proteins. • Ascl1-induced neurons are functional generating action potentials.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2014-09, Vol.275, p.125-135
Hauptverfasser: Nishimura, K, Weichert, R.M, Liu, W, Davis, R.L, Dabdoub, A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Auditory Pathways - cytology
Auditory Pathways - physiology
Cell Count
Cell Differentiation - physiology
Cochlea - cytology
Cochlea - physiology
Hearing - physiology
Mice
Neurology
Neurons - cytology
Neurons - physiology
Regeneration - physiology
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Beschreibung
Zusammenfassung:Highlights • Ascl1 induces neurons at high efficiency in the embryonic, postnatal and juvenile mouse cochlea. • Ascl1-induced neurons express several neuronal markers including synaptic proteins. • Ascl1-induced neurons are functional generating action potentials.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.067