Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection

Highlights • Endothelial cells are important in the development of plasma leakage during dengue. • Markers produced by endothelial cells in relation to plasma leakage were investigated. • Levels of angiopoietin-2 were increased in dengue patients with plasma leakage. • Levels of sVEGFR-2 were decrea...

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Veröffentlicht in:	Journal of clinical virology 2014-08, Vol.60 (4), p.328-335
Hauptverfasser:	van de Weg, Cornelia A.M, Pannuti, Cláudio S, van den Ham, Henk-Jan, de Araújo, Evaldo S.A, Boas, Lucy S.V, Felix, Alvina C, Carvalho, Karina I, Levi, José E, Romano, Camila M, Centrone, Cristiane C, Rodrigues, Celia L. de Lima, Luna, Expedito, van Gorp, Eric C.M, Osterhaus, Albert D.M.E, Kallas, Esper G, Martina, Byron E.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Angiopoietin-2 Angiopoietin-2 - blood Antibodies, Viral - immunology Antibody Affinity - immunology Biomarkers - blood Brazil Capillary Permeability - physiology Case-Control Studies Child Dengue virus Dengue Virus - pathogenicity Endothelial Cells - pathology Endothelial Cells - virology Endothelin-1 - blood Female Humans Immunoglobulin G - immunology Infectious Disease Male Matrix Metalloproteinase 2 - blood Middle Aged Plasma leakage Radiography Severe Dengue - blood Severe Dengue - diagnostic imaging Severe Dengue - virology Soluble VEGFR-2 Vascular Endothelial Growth Factor Receptor-2 - blood Vascular permeability Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Endothelial cells are important in the development of plasma leakage during dengue. • Markers produced by endothelial cells in relation to plasma leakage were investigated. • Levels of angiopoietin-2 were increased in dengue patients with plasma leakage. • Levels of sVEGFR-2 were decreased in dengue patients with plasma leakage. • Angiopoietin-2 and sVEGFR-2 can serve as surrogate markers for plasma leakage.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.05.001