Linking pathways in the developing and aging brain with neurodegeneration

Highlights • We review common pathways of the developing and aging brain. • Proteins that are important in neurodegeneration play a role in the developing brain. • Understanding neurogenesis has implications for reversing neurodegeneration. • Prevention of age-related neurodegeneration might begin d...

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Veröffentlicht in:	Neuroscience 2014-06, Vol.269, p.152-172
Hauptverfasser:	Kovacs, G.G, Adle-Biassette, H, Milenkovic, I, Cipriani, S, van Scheppingen, J, Aronica, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biological and medical sciences brain Brain - growth & development Brain - physiology Brain - physiopathology development developmental pathways Fundamental and applied biological sciences. Psychology human Humans neurodegeneration neurodegenerative disease-associated proteins Neurodegenerative Diseases - physiopathology Neurogenesis - physiology Neurology Signal Transduction - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • We review common pathways of the developing and aging brain. • Proteins that are important in neurodegeneration play a role in the developing brain. • Understanding neurogenesis has implications for reversing neurodegeneration. • Prevention of age-related neurodegeneration might begin during the fetal life.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.03.045