Angiotensinergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates the pressor response to acute restraint stress in rats

Highlights • The highest i.v. dose of losartan inhibited the cardiovascular response of stress. • I.v. injection of losartan acts across the blood–brain barrier, possibly in the PVN. • The losartan or lisinopril into the PVN inhibited the pressor response of stress. • PVN AT1-receptors modulate the...

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Veröffentlicht in:	Neuroscience 2014-06, Vol.270, p.12-19
Hauptverfasser:	Busnardo, C, Tavares, R.F, Correa, F.M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	angiontensin AT1 receptor Angiotensin II Type 1 Receptor Blockers - pharmacology angiotensin-converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology Cardiovascular Physiological Phenomena - drug effects Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Heart Rate - physiology Lisinopril - pharmacology Losartan - pharmacology Male Neurology Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiopathology paraventricular nucleus of the hypothalamus Rats Rats, Wistar Receptor, Angiotensin, Type 1 - metabolism restraint stress Restraint, Physical Stress, Psychological - drug therapy Stress, Psychological - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tachycardia - physiopathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • The highest i.v. dose of losartan inhibited the cardiovascular response of stress. • I.v. injection of losartan acts across the blood–brain barrier, possibly in the PVN. • The losartan or lisinopril into the PVN inhibited the pressor response of stress. • PVN AT1-receptors modulate the vascular component of the stress response.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.03.064