Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocortic...
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| Veröffentlicht in: | Environmental science & technology 2014-11, Vol.48 (21), p.12902-12911 |
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| creator | Macikova, Petra Groh, Ksenia J Ammann, Adrian A Schirmer, Kristin Suter, Marc J.-F |
| description | This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from |
| doi_str_mv | 10.1021/es502711c |
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Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from <LOD–2.6, 19–37, and 78–542 ng/L for river water, treated, and untreated wastewater, respectively. For most samples, the chemically predicted GR-mediated response was higher than that determined by the bioassay. Correspondingly, antiglucocorticoid activity was observed in some fractions. The fish plasma model (FPM), which predicts plasma concentrations, was applied to evaluate the potential of detected pharmaceuticals to cause receptor-mediated effects in fish. With one exception, medroxyprogesterone, the FPM applied to individual compounds predicted fish plasma concentrations to be below the level of human therapeutic plasma concentrations. To account for the activity of the sum of GR-active compounds, we introduce the “cortisol equivalents fish plasma concentration” approach, through which an increase in fish glucocorticoid plasma levels comparable to 0.9–83 ng/mL cortisol after exposure to the analyzed river waters was estimated. The results suggest that these chemicals may impact wild fish.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es502711c</identifier><identifier>PMID: 25269596</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Adrenal Cortex Hormones - metabolism ; Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Bioassays ; Biological and medical sciences ; Biological Assay - methods ; Chromatography, High Pressure Liquid - methods ; Czech Republic ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Endocrine Disruptors - analysis ; Environment ; Fish ; Fishes - blood ; Fishes - metabolism ; Fresh Water - analysis ; Fresh Water - chemistry ; Fundamental and applied biological sciences. Psychology ; Hormones ; Humans ; Plasma ; Rivers ; Rivers - chemistry ; Signal transduction ; Steroids ; Switzerland ; Tandem Mass Spectrometry - methods ; Toxicity Tests - methods ; Waste Water - analysis ; Water ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - blood ; Water Pollutants, Chemical - pharmacokinetics ; Water Pollutants, Chemical - toxicity</subject><ispartof>Environmental science & technology, 2014-11, Vol.48 (21), p.12902-12911</ispartof><rights>Copyright © 2014 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Nov 4, 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a507t-9afa3f9656c53ee367f8c7e38e7078b1ff0466accfa646e12f2a2423959c21763</citedby><cites>FETCH-LOGICAL-a507t-9afa3f9656c53ee367f8c7e38e7078b1ff0466accfa646e12f2a2423959c21763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es502711c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es502711c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28965839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25269596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macikova, Petra</creatorcontrib><creatorcontrib>Groh, Ksenia J</creatorcontrib><creatorcontrib>Ammann, Adrian A</creatorcontrib><creatorcontrib>Schirmer, Kristin</creatorcontrib><creatorcontrib>Suter, Marc J.-F</creatorcontrib><title>Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from <LOD–2.6, 19–37, and 78–542 ng/L for river water, treated, and untreated wastewater, respectively. For most samples, the chemically predicted GR-mediated response was higher than that determined by the bioassay. Correspondingly, antiglucocorticoid activity was observed in some fractions. The fish plasma model (FPM), which predicts plasma concentrations, was applied to evaluate the potential of detected pharmaceuticals to cause receptor-mediated effects in fish. With one exception, medroxyprogesterone, the FPM applied to individual compounds predicted fish plasma concentrations to be below the level of human therapeutic plasma concentrations. To account for the activity of the sum of GR-active compounds, we introduce the “cortisol equivalents fish plasma concentration” approach, through which an increase in fish glucocorticoid plasma levels comparable to 0.9–83 ng/mL cortisol after exposure to the analyzed river waters was estimated. The results suggest that these chemicals may impact wild fish.</description><subject>Adrenal Cortex Hormones - metabolism</subject><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Bioassays</subject><subject>Biological and medical sciences</subject><subject>Biological Assay - methods</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Czech Republic</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Endocrine Disruptors - analysis</subject><subject>Environment</subject><subject>Fish</subject><subject>Fishes - blood</subject><subject>Fishes - metabolism</subject><subject>Fresh Water - analysis</subject><subject>Fresh Water - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Plasma</subject><subject>Rivers</subject><subject>Rivers - chemistry</subject><subject>Signal transduction</subject><subject>Steroids</subject><subject>Switzerland</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Toxicity Tests - methods</subject><subject>Waste Water - analysis</subject><subject>Water</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - blood</subject><subject>Water Pollutants, Chemical - pharmacokinetics</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c9rFDEUB_Agil2rB_8BCYigh9H82Eky3sraaqFgQUVvw2s26abMJNO8DKUe_NvN2rUVvXgK5H14yfs-Qp5y9pozwd84bJnQnNt7ZMFbwZrWtPw-WTDGZdNJ9W2PPEK8YIwJycxDsidaobq2Uwvy4zCuk80hOvouYJ6nEuI5XaVxSnNcIz3w3tndXS7BJiwup7Cmn8J5hGFbOIWyuYJrpCHS1XdnNxRirV8FRPoVKse39DQVF0uAgR6PE9hCU6RHATePyQMPA7onu3OffDk6_Lz60Jx8fH-8OjhpoGW6NB14kL5TrbKtdE4q7Y3VThqnmTZn3Hu2VAqs9aCWynHhBYilkHVGK7hWcp-8vOk75XQ5Oyz9GNC6YYDo0ow9V0J3mi8N-x_KtvkKXenzv-hFmnON5ZcSUigpTFWvbpTNCTE73085jJCve8767f762_1V-2zXcT4b3fpW_l5YBS92ANDC4DNEG_DOmRqSkd2dA4t__OqfB38C6-quFw</recordid><startdate>20141104</startdate><enddate>20141104</enddate><creator>Macikova, Petra</creator><creator>Groh, Ksenia J</creator><creator>Ammann, Adrian A</creator><creator>Schirmer, Kristin</creator><creator>Suter, Marc J.-F</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7QH</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20141104</creationdate><title>Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish</title><author>Macikova, Petra ; Groh, Ksenia J ; Ammann, Adrian A ; Schirmer, Kristin ; Suter, Marc J.-F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a507t-9afa3f9656c53ee367f8c7e38e7078b1ff0466accfa646e12f2a2423959c21763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adrenal Cortex Hormones - metabolism</topic><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Bioassays</topic><topic>Biological and medical sciences</topic><topic>Biological Assay - methods</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Czech Republic</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Endocrine Disruptors - analysis</topic><topic>Environment</topic><topic>Fish</topic><topic>Fishes - blood</topic><topic>Fishes - metabolism</topic><topic>Fresh Water - analysis</topic><topic>Fresh Water - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Plasma</topic><topic>Rivers</topic><topic>Rivers - chemistry</topic><topic>Signal transduction</topic><topic>Steroids</topic><topic>Switzerland</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Toxicity Tests - methods</topic><topic>Waste Water - analysis</topic><topic>Water</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - blood</topic><topic>Water Pollutants, Chemical - pharmacokinetics</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macikova, Petra</creatorcontrib><creatorcontrib>Groh, Ksenia J</creatorcontrib><creatorcontrib>Ammann, Adrian A</creatorcontrib><creatorcontrib>Schirmer, Kristin</creatorcontrib><creatorcontrib>Suter, Marc J.-F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Environmental science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macikova, Petra</au><au>Groh, Ksenia J</au><au>Ammann, Adrian A</au><au>Schirmer, Kristin</au><au>Suter, Marc J.-F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2014-11-04</date><risdate>2014</risdate><volume>48</volume><issue>21</issue><spage>12902</spage><epage>12911</epage><pages>12902-12911</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from <LOD–2.6, 19–37, and 78–542 ng/L for river water, treated, and untreated wastewater, respectively. For most samples, the chemically predicted GR-mediated response was higher than that determined by the bioassay. Correspondingly, antiglucocorticoid activity was observed in some fractions. The fish plasma model (FPM), which predicts plasma concentrations, was applied to evaluate the potential of detected pharmaceuticals to cause receptor-mediated effects in fish. With one exception, medroxyprogesterone, the FPM applied to individual compounds predicted fish plasma concentrations to be below the level of human therapeutic plasma concentrations. To account for the activity of the sum of GR-active compounds, we introduce the “cortisol equivalents fish plasma concentration” approach, through which an increase in fish glucocorticoid plasma levels comparable to 0.9–83 ng/mL cortisol after exposure to the analyzed river waters was estimated. The results suggest that these chemicals may impact wild fish.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>25269596</pmid><doi>10.1021/es502711c</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal Cortex Hormones - metabolism Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Bioassays Biological and medical sciences Biological Assay - methods Chromatography, High Pressure Liquid - methods Czech Republic Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endocrine Disruptors - analysis Environment Fish Fishes - blood Fishes - metabolism Fresh Water - analysis Fresh Water - chemistry Fundamental and applied biological sciences. Psychology Hormones Humans Plasma Rivers Rivers - chemistry Signal transduction Steroids Switzerland Tandem Mass Spectrometry - methods Toxicity Tests - methods Waste Water - analysis Water Water Pollutants, Chemical - analysis Water Pollutants, Chemical - blood Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity |
| title | Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish |
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