Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish

This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocortic...

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Veröffentlicht in:	Environmental science & technology 2014-11, Vol.48 (21), p.12902-12911
Hauptverfasser:	Macikova, Petra, Groh, Ksenia J, Ammann, Adrian A, Schirmer, Kristin, Suter, Marc J.-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - metabolism Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Bioassays Biological and medical sciences Biological Assay - methods Chromatography, High Pressure Liquid - methods Czech Republic Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endocrine Disruptors - analysis Environment Fish Fishes - blood Fishes - metabolism Fresh Water - analysis Fresh Water - chemistry Fundamental and applied biological sciences. Psychology Hormones Humans Plasma Rivers Rivers - chemistry Signal transduction Steroids Switzerland Tandem Mass Spectrometry - methods Toxicity Tests - methods Waste Water - analysis Water Water Pollutants, Chemical - analysis Water Pollutants, Chemical - blood Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity
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Zusammenfassung:	This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from
ISSN:	0013-936X 1520-5851
DOI:	10.1021/es502711c