Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy

The role of nitric oxide (NO) on leucocyte migration has been investigated in rat carrageenin-induced pleurisy. Male Wistar rats. L-arginine, NOC-18 and aminoguanidine were administered subcutaneously 1 h prior to carrageenin injection. Leucocyte accumulation into the pleural cavity was measured 4 h...

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Veröffentlicht in:	Inflammation research 2000-08, Vol.49 (8), p.411-417
Hauptverfasser:	Ialenti, A, Ianaro, A, Maffia, P, Sautebin, L, Di Rosa, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - administration & dosage Arginine - pharmacology Blood Pressure Carrageenan Cell Movement - drug effects Enzyme Inhibitors - pharmacology Guanidines - administration & dosage Guanidines - pharmacology Leukocytes - physiology Male Nitric Oxide - pharmacology Nitric Oxide Donors - administration & dosage Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Nitroso Compounds - administration & dosage Nitroso Compounds - pharmacology Pleura - pathology Pleural Effusion - pathology Pleural Effusion - physiopathology Pleurisy - chemically induced Pleurisy - pathology Rats Rats, Wistar
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Zusammenfassung:	The role of nitric oxide (NO) on leucocyte migration has been investigated in rat carrageenin-induced pleurisy. Male Wistar rats. L-arginine, NOC-18 and aminoguanidine were administered subcutaneously 1 h prior to carrageenin injection. Leucocyte accumulation into the pleural cavity was measured 4 h after carrageenin challenge. Statistical significance was calculated by Bonferroni test. L-arginine (10 mg/kg) or the NO donor NOC-18 (10 mg/kg), significantly inhibited leucocyte infiltration by 31% and 20% respectively (P
ISSN:	1023-3830 1420-908X
DOI:	10.1007/s000110050609