Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice

Highlights • The KA-induced hippocampal CA3 neuronal death was attenuated by repaglinide. • Repaglinide attenuated the elevation of the blood glucose level induced by KA. • Repaglinide attenuated KA-induced up-regulation of plasma corticosterone level. • KA-mediated reduction in insulin level was re...

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Veröffentlicht in:	Brain research bulletin 2014-05, Vol.104, p.36-41
Hauptverfasser:	Kim, Chea-Ha, Park, Soo-Hyun, Sim, Yun-Beom, Kim, Sung-Su, Kim, Su-Jin, Lim, Su-Min, Jung, Jun-Sub, Suh, Hong-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood glucose Blood Glucose - drug effects Blood Glucose - metabolism CA3 Region, Hippocampal - drug effects Carbamates - administration & dosage Carbamates - pharmacology Cell Death Corticosterone - blood Cyclohexanes - administration & dosage Cyclohexanes - pharmacology Excitatory Amino Acid Agonists - toxicity Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Infusions, Intraventricular Insulin - blood Kainic acid Kainic Acid - toxicity Male Megltinide Mice Mice, Inbred ICR Neurology Neuronal cell death Neurons - drug effects Phenylalanine - administration & dosage Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Piperidines - administration & dosage Piperidines - pharmacology
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Zusammenfassung:	Highlights • The KA-induced hippocampal CA3 neuronal death was attenuated by repaglinide. • Repaglinide attenuated the elevation of the blood glucose level induced by KA. • Repaglinide attenuated KA-induced up-regulation of plasma corticosterone level. • KA-mediated reduction in insulin level was reversed by repaglinide injection.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.02.003