Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping

Highlights • Upregulation of matrix metalloproteinase MMP12 in regenerating motor neurons. • Neuronal MMP12 expression precedes peak of experimentally induced synaptic. • Neuronal MMP12 becomes localized beneath the neuronal somatic membrane. • A role for MMP12 in the neuronal initiation of the syna...

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Veröffentlicht in:	Neuroscience 2014-08, Vol.274, p.331-340
Hauptverfasser:	Sajjan, S, Holsinger, R.M.D, Fok, S, Ebrahimkhani, S, Rollo, J.L, Banati, R.B, Graeber, M.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Membrane - metabolism extracellular matrix facial nerve axotomy Facial Nerve Injuries - physiopathology Facial Nucleus - physiology Fundamental and applied biological sciences. Psychology Intracellular Space - metabolism matrikines Matrix Metalloproteinase 12 - metabolism metzincins Mice Mice, Inbred C57BL Motor Neurons - physiology Nerve Regeneration - physiology Neuroglia - physiology Neurology Neuronal Plasticity - physiology Rats, Inbred Lew statins Synapses - physiology synaptic plasticity Up-Regulation Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Upregulation of matrix metalloproteinase MMP12 in regenerating motor neurons. • Neuronal MMP12 expression precedes peak of experimentally induced synaptic. • Neuronal MMP12 becomes localized beneath the neuronal somatic membrane. • A role for MMP12 in the neuronal initiation of the synaptic stripping process is suggested. • Interference with synaptic stability may explain CNS side effects of statins.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.05.052