OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing

OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing

•Zebrafish embryo acute toxicity test (ZFET) validated for aquatic toxicity testing.•20 chemicals tested in 11 laboratories with standardised ZFET protocol.•ZFET shows good within- and between laboratory reproducibility (CV

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Bibliographische Detailangaben
Veröffentlicht in:Regulatory toxicology and pharmacology 2014-08, Vol.69 (3), p.496-511
Hauptverfasser: Busquet, François, Strecker, Ruben, Rawlings, Jane M., Belanger, Scott E., Braunbeck, Thomas, Carr, Gregory J., Cenijn, Peter, Fochtman, Przemyslaw, Gourmelon, Anne, Hübler, Nicole, Kleensang, André, Knöbel, Melanie, Kussatz, Carola, Legler, Juliette, Lillicrap, Adam, Martínez-Jerónimo, Fernando, Polleichtner, Christian, Rzodeczko, Helena, Salinas, Edward, Schneider, Katharina E., Scholz, Stefan, van den Brandhof, Evert-Jan, van der Ven, Leo T.M., Walter-Rohde, Susanne, Weigt, Stefan, Witters, Hilda, Halder, Marlies
Format: Artikel
Sprache:eng
Schlagworte:
Alternative method
Animals
Aquatic acute toxicity
Danio rerio
Laboratories
Lethal Dose 50
Organisation for Economic Co-Operation and Development
Reproducibility
Reproducibility of Results
Toxicity Tests, Acute - methods
Validation
Water Pollutants, Chemical - toxicity
Zebrafish
Zebrafish embryo
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Beschreibung
Zusammenfassung:•Zebrafish embryo acute toxicity test (ZFET) validated for aquatic toxicity testing.•20 chemicals tested in 11 laboratories with standardised ZFET protocol.•ZFET shows good within- and between laboratory reproducibility (CV
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2014.05.018