Viral evolutionary changes during tenofovir treatment in a chronic hepatitis B patient with sequential nucleos(t)ide therapy

Highlights • Tenofovir (TDF) showed a favorable resistance profile. • The resistance mutations of TDF have not been identified through several years. • This patient experienced virological breakthrough under TDF without rtA194T. • TDF resistance may emerge due to multi-site polymerase mutations. • P...

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Veröffentlicht in:	Journal of clinical virology 2014-07, Vol.60 (3), p.313-316
Hauptverfasser:	Lee, Hyun Woong, Chang, Hye Young, Yang, Suh Yoon, Kim, Hyung Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Allergy and Immunology Antiviral Agents - therapeutic use Chronic hepatitis B Drug Resistance, Viral Drug Substitution Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Infectious Disease Male Middle Aged Mutation Organophosphonates - therapeutic use Resistance Reverse Transcriptase Inhibitors - therapeutic use Tenofovir Treatment Outcome Viral Load
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Beschreibung
Zusammenfassung:	Highlights • Tenofovir (TDF) showed a favorable resistance profile. • The resistance mutations of TDF have not been identified through several years. • This patient experienced virological breakthrough under TDF without rtA194T. • TDF resistance may emerge due to multi-site polymerase mutations. • Patients with sustained detectable HBV DNA should be monitored for TDF resistance.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.03.018