Enantioposition-Selective Copper-Catalyzed Azide–Alkyne Cycloaddition for Construction of Chiral Biaryl Derivatives
A highly enantioposition-selective copper-catalyzed azide–alkyne cycloaddition (CuAAC) of dialkynes bearing prochiral biaryls has been developed for the construction of 1,2,3-triazoles bearing axially chiral biaryl groups in up to 76% yield and up to 99% ee.
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| Veröffentlicht in: | Organic letters 2014-11, Vol.16 (22), p.5866-5869 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A highly enantioposition-selective copper-catalyzed azide–alkyne cycloaddition (CuAAC) of dialkynes bearing prochiral biaryls has been developed for the construction of 1,2,3-triazoles bearing axially chiral biaryl groups in up to 76% yield and up to 99% ee. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol502778j |