Heavier Alkaline Earth Catalyzed Ene-yne Cyclizations: Atom-Efficient Access to Tetrahydroisoquinoline Frameworks

Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2014-11, Vol.16 (22), p.6016-6019
Hauptverfasser:	Reid, Stephanie, Barrett, Anthony G. M, Hill, Michael S, Procopiou, Panayiotis A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Alkynes - chemistry Amines - chemistry Catalysis Combinatorial Chemistry Techniques Cyclization Molecular Structure Tetrahydroisoquinolines - chemical synthesis Tetrahydroisoquinolines - chemistry
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Beschreibung
Zusammenfassung:	Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol502600g