Genetic linkage map of facioscapulohumeral muscular dystrophy and five polymorphic loci on chromosome 4q35-pter

Genetic linkage map of facioscapulohumeral muscular dystrophy and five polymorphic loci on chromosome 4q35-pter

A genetic map of five polymorphic markers in the area of the facioscapulohumeral muscular dystrophy (FSHD) gene on chromosome 4q35-pter has been constructed. With these five markers, a number of recombinants have been identified that allow ordering of the marker and the disease loci. The most likely...

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Veröffentlicht in:American journal of human genetics 1992-01, Vol.51 (2), p.441-415
Hauptverfasser: Wijmenga, C, Sandkuijl, LA, Moerer, P, van der Boorn, N, Bodrug, SE, Ray, P N, Brouwer, OF, Murray, J C, Frants, R R
Format: Artikel
Sprache:eng
Schlagworte:
chromosome 4
facioscapulohumeral muscular dystrophy
linkage analysis
man
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Zusammenfassung:A genetic map of five polymorphic markers in the area of the facioscapulohumeral muscular dystrophy (FSHD) gene on chromosome 4q35-pter has been constructed. With these five markers, a number of recombinants have been identified that allow ordering of the marker and the disease loci. The most likely locus order and the relative position of the FSHD gene supported by the recombinants is centromere-D4S171-F11-D4S187-D4S163-D4S139-FSHD-telomere.
ISSN:0002-9297