Cellular expression of the cytolytic factor in earthworms Eisenia foetida

Cellular expression of the cytolytic factor in earthworms Eisenia foetida

Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40% of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on f...

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Veröffentlicht in:Immunology letters 1998, Vol.60 (1), p.23-29
Hauptverfasser: Bilej, Martin, Rossmann, Pavel, Šinkora, Marek, Hanušová, Radka, Beschin, Alain, Raes, Geert, De Baetselier, Patrick
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chloragogenous tissue
Coelomic cytolytic factor 1 (CCF-1)
Coelomic fluid
Coelomocytes
Cytotoxicity Tests, Immunologic
Cytotoxins - biosynthesis
Eisenia foetida
Lectins
Lipopolysaccharide
Lipopolysaccharides - pharmacology
Oligochaeta - immunology
TNF
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Zusammenfassung:Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40% of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on free coelomocytes. Both cellular and humoral levels of CCF-1 were significantly increased after parenteral injection of endotoxin. Moreover, CCF-1 seems to be involved in cell mediated cytotoxicity, because cytotoxic activity is blocked in the presence of anti-CCF-1 monoclonal antibody (mAb).
ISSN:0165-2478
1879-0542
DOI:10.1016/S0165-2478(97)00127-2